Page 18 - HKSEMR2020 Programme book

Oral Presentation (Clinical) Abstracts

Trabecular bone score: Normative reference data in Chinese men

and women in Hong Kong and ability to predict incident fractures

Eunice K.H. Leung, Joanne K.Y. Lam, Kathryn C.B. Tan
Queen Mary Hospital

Introduction / Background / Objectives: 4,313 participants who were eligible of analysis for TBS and
risk of major osteoporotic fracture. During a mean follow-up of
Trabecular bone score (TBS) is an indirect index of bone
microarchitecture that predicts incident fractures. We aimed to 14±3 years, 292 subjects (6.8%) suffered from incident major
develop a normative reference dataset for TBS in Hong Kong and osteoporotic fracture, and were older compared with those without
examine the predictive ability of TBS in incident fractures. incident fracture. They also had lower lumbar spine bone mineral
density (BMD), femoral neck BMD and TBS. Multivariable Cox
regression analysis showed that TBS was an independent risk

Methods: factor for major osteoporotic fracture. The hazard ratio per standard
deviation of decline in TBS was 1.37 (1.16-1.63, p < 0.001) after
TBS data collected from 5,343 Chinese men and women enrolled adjustment for clinical risk factors and femoral neck BMD.
in the Hong Kong Osteoporosis Study were analyzed. Clinical
fracture events were identified from the Clinical Data Analysis and
Reporting System up to 1st January 2019. Conclusion:
TBS is an independent risk factor for major osteoporotic fracture.
Results / Outcomes: Further analysis is required to determine whether TBS can improve
incident fracture prediction in addition to femoral neck BMD and
We identified 987 men and 2,542 women were eligible for Fracture Risk Assessment Tool.
generation of the normative reference dataset. There was a linear
relationship between age and TBS in both sexes.

16